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ORC-001
Oncology
Discovery
Preclinical
Clinical
Regulatory
Accelerate IND timeline
ORC-002
Autoimmune
Initiate backup to derisk ORC-002
Metabolic
Partner milestones at risk
Clear alignment between cross-functional teams
Align trade-offs with resource constraints
Understand how program changes impact your entire portfolio
Efficacy studies
IND filing
Backup GMP production
In vivo GLP studies
Cell line development
Assay development
$3M and 18w
Safety/toxicity studies
Process development
Antibody optimization
GMP production
Tara · CEO
What can we do to make sure ORC-002 is ready for Phase 1 trials next year?
Overview and scenarios
Portfolio decisions
Ashoka · Program Manager
Would we reach IND faster if we ran in vivo efficacy studies in parallel to our backup screens?
Trey · CMC Lead
Can we ramp up production so that we can increase trial enrollment?
Study readouts
Timelines and resources
Ky · Scientist
If this run is late, what are the downstream impacts? Should we adjust?
Experiments and data
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